Innovation and Nanotechnologies
Camille's PhD research focused on Synthetic Biology and harnessed the incredible modularity of the RNA molecule for biofuel and drug production.
Spatial organization of metabolic pathways within cells is important and found in many organisms. It enables to isolate multi-enzymatic reactions, improves yields and robustness.
Synthetic Biology lacked modular tools for de novo intra-cellular spatial organization of metabolic pathways. Camille and his colleagues have engineered non-coding RNAs to act as "artificial organelles". The main results were published in Science in July 2011 and the contribution made the cover of the issue. It has already cited over 180 times.
C. J. Delebecque, P. A. Silver, A. B. Lindner. Designing and Using RNA Scaffolds to Assemble Proteins in vivo. (2012) Nature Protocols, 7 :1797-1807. (PDF)
C. J. Delebecque, A. B. Lindner, P. A. Silver, F. A. Aldaye (2011);Organization of Intracellular Reactions with Rationally Designed RNA Assemblies; Science 333:470-474. (PDF)